circRNA basic information
circBase ID: -
Name: hsa_circ_ADAM
Synonym: circADAM
Host Gene: hsa-miR-545-3p
 
 
 
Disease basic information
DO ID:
 9743
DO name: diabetic neuropathy
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: cell line
Sample type details: human mesangial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: USP15
Associated microRNA: hsa-miR-545-3p
Biological function: CircADAM9 was upregulated in DN samples and HG-treated HMCs, while its downregulation inhibited cell proliferation, inflammation, fibrosis, and oxidative stress.
Molecular mechanism: circADAM9 exerted this influence by targeting the miR-545-3p/USP15 axis, thereby regulating the KELCH-like ECh-associated protein 1/nuclear factor erythroid 2 related factor 2 (Keap1/Nrf2) pathway.
Survival: -
Supported No.:
 1
Description:

the circADAM9/miR-545-3p/USP15/Keap1/Nrf2 signaling axis is critical for HG-induced cell injury in HMCs and might represent a novel therapeutic target for DN treatment.
Other information
Title:

Circular RNA circADAM9 Promotes Inflammation, Oxidative Stress, and Fibrosis of Human Mesangial Cells via the Keap1-Nrf2 Pathway in Diabetic Nephropathy.

Journal: Exp Clin Endocrinol Diabetes
Published: 2023/7/19
PubMed ID: 37463596