circRNA basic information
circBase ID: hsa_circ_0072568
Name: -
Synonym: Circ0072568
Host Gene: hsa-miR_382_5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: chondrocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: TOP1
Associated microRNA: hsa-miR_382_5p
Biological function: Circ0072568 was inhibited in OA tissues and the cell model_n vitro. Circ0072568 overexpression protected the chondrocytes against IL-1beta-induced inflammation and extracellular matrix (ECM) breakdown.
Molecular mechanism: Circ0072568 directly attached to microRNA (miR)-382-5p and enhanced the production of topoisomerase 1 (TOP1).
Survival: -
Supported No.:
 2
Description:

On the whole, the present study demonstrates that the Circ0072568/miR-382-5p/TOP1 axis is involved in inflammation and ECM degradation in OA. These findings may contribute to the development of potential therapeutic strategies for OA.
Other information
Title:

Protective effects of hsa_circ_0072568 on interleukin_1beta__timulated human chondrocytes are mediated via the miR_382_5p/TOP1 axis.

Journal: Exp Ther Med
Published: 2023/7/17
PubMed ID: 37456162