circRNA basic information
circBase ID: -
Name: hsa_circ_FOXP1
Synonym: circFOXP1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3770
DO name: pulmonary fibrosis
Disease details: pulmonary fibrosis
Species: human
Species details: human
Sample type: cell line
Sample type details: MRC-5 cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: EZH2
Associated microRNA: -
Biological function: circFOXP1-mediated autophagic mechanism of hucMSCs treatment.
Molecular mechanism: The inhibition of hucMSCs treatment on pulmonary fibrogenesis depended on downregulating circFOXP1, in which hucMSCs treatment promoted circFOXP1-mediated autophagy process via blocking the nuclear human antigen R (HuR) translocation and promoting the HuR degradation, leading to a marked decrease in autophagy negative regulators EZH2, STAT1 and FOXK1.
Survival: -
Supported No.:
 1
Description:

In conclusion, hucMSCs treatment significantly improved pulmonary fibrosis by downregulating the circFOXP1-HuR-EZH2/STAT1/FOXK1 autophagic axis. hucMSCs can act as an effective treatment for pulmonary fibrosis.
Other information
Title:

hucMSCs treatment ameliorated pulmonary fibrosis via downregulating the circFOXP1-HuR-EZH2/STAT1/FOXK1 autophagic axis.

Journal: Stem Cells
Published: 2023/7/8
PubMed ID: 37419489