circRNA basic information
circBase ID: -
Name: hsa_circ_CAPG
Synonym: circCAPG
Host Gene: -
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MDA-MB-23, MDA-MB-468, HEK293T, Hs578T, MCF7, T47D, ZR-75-1, MCF-10
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: MEKK2, MEK1, MEK2, ERK1, ERK2, SLU7, STK38, SMURF1
Associated microRNA: -
Biological function: In addition, we found that circCAPG knockdown (KD) significantly inhibited the growth of TNBC organoids.
Molecular mechanism: circCAPG/CAPG-171aa/MEKK2-MEK1/2-ERK1/2 pathway
Survival: poor
Supported No.:
 1
Description:

circCAPG significantly enhances the proliferation and metastasis of TNBC cells by encoding a novel polypeptide CAPG-171aa and afterwards activates MEKK2-MEK1/2-ERK1/2 pathway.
Other information
Title:

A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer

Journal: Mol Cancer
Published: 2023/7/5
PubMed ID: 37408008