circRNA basic information
circBase ID: hsa_circ_0001451
Name: hsa_circ_FBXW7
Synonym: circ-FBXW7
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circFBXW7 inhibits the renewal of cancer stem cells and resensitizes both resistant LUAD cells and stem cells to Osimertinib
Molecular mechanism: Wnt signaling
Survival: -
Supported No.:
 1
Description:

Our bench study, in vivo experiments, and clinical validation have unequivocally shown that circFBXW7 effectively inhibits the abilities of LUAD stem cells and reverses resistance to TKIs by modulating Wnt pathway functions through the action of circFBXW7-185AA on beta-catenin ubiquitination and inhibition.
Other information
Title:

Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7.

Journal: Mol Cancer
Published: 2023/7/2
PubMed ID: 37393311