circRNA basic information
circBase ID: hsa_circ_0003596
Name: hsa_circ_COL5A1
Synonym: circ_0003596
Host Gene: hsa-miR-502-5p
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: clear cell renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: One normal human kidney cell line (HK-2), four kidney cancer cell lines (786-O, Caki-1, Caki-2, ACHN)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF1
Associated microRNA: hsa-miR-502-5p
Biological function: the knockdown of hsa_circ_0003596 can lower the proliferation, infiltration and migration potential of ccRCC cells
Molecular mechanism: circ_0003596/hsa-miR-502-5p/IGF1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Overall, the results of the present study showed that hsa_circ_0003596 facilitated the proliferation, infiltration and migration of ccRCC through the miR-502-5p/IGF1R/PI3K/AKT axis.
Other information
Title:

Hsa_circ_0003596 enhances the development of cell renal clear cell carcinoma through the miR-502-5p/IGF1/PI3K/AKT axis.

Journal: J Gene Med
Published: 2023/7/1
PubMed ID: 37392008