circRNA basic information
circBase ID: hsa_circ_0084922
Name: hsa_circ_KIAA1429
Synonym: -
Host Gene: hsa-miR-133a-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A normal liver derived cell line (THLE-2), HCC cell lines (HCCLM3, Huh7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: METTL3, HMGA2
Associated microRNA: hsa-miR-133a-3p
Biological function: deletion of both circ_KIAA1429 and METTL3 suppressed HCC cell proliferation, migration and cell mitosis in vitro and in vivo, and conversely, circ_KIAA1429 overexpression had opposite effects to accelerate HCC development
Molecular mechanism: METTL3/m6A/circ_KIAA1429/hsa-miR-133a-3p/HMGA2 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

To summarize, our study firstly investigated the involvement of a novel METTL3/m6A/circ_KIAA1429/miR-133a-3p/HMGA2 axis in regulating HCC development, which provided novel indicators for HCC diagnosis, therapy and prognosis.
Other information
Title:

Circular RNA circ_KIAA1429 accelerates hepatocellular carcinoma progression via the miR-133a-3p/high mobility group AT-hook 2 (HMGA2) axis in an m6A-dependent manner.

Journal: Hum Cell
Published: 2023/6/27
PubMed ID: 37368192