circRNA basic information
circBase ID: -
Name: hsa_circ_Itgb5
Synonym: circItgb5
Host Gene: hsa-miR-96-5p
 
 
 
Disease basic information
DO ID:
 6432
DO name: pulmonary hypertension
Disease details: monocrotaline-induced pulmonary arterial hypertension
Species: human
Species details: human
Sample type: cell line
Sample type details: PASMCs
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: Uba1
Associated microRNA: hsa-miR-96-5p
Biological function: In vivo experiments revealed that the knockdown of circItgb5 attenuated MCT-induced pulmonary vascular remodeling and right ventricular hypertrophy. In vitro experiments revealed that circItgb5 promoted the transition of PASMCs to synthetic phenotype
Molecular mechanism: CircItgb5/hsa-miR-96-5p/Uba1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

CircItgb5 promoted the transition of PASMCs to synthetic phenotype by interacting with miR-96-5p and Uba1 protein.
Other information
Title:

CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension.

Journal: Respir Res
Published: 2023/6/22
PubMed ID: 37344798