circRNA basic information
circBase ID: -
Name: hsa_circ_ARF3
Synonym: CircARF3
Host Gene: hsa-miR-205-5p
 
 
 
Disease basic information
DO ID:
 4481
DO name: allergic rhinitis
Disease details: allergic rhinitis
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: Nasal epithelial cell
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: SIRT5
Associated microRNA: hsa-miR-205-5p
Biological function: circARF3 overexpression alleviated histological abnormalities, apoptosis, inflammatory response, and HMGB1/TLR4 signaling activation in HDM-treated animals.
Molecular mechanism: CircARF3 was generated by back-splicing exons 3-5 with a stable circular shape. CircARF3 overexpression mitigated IL-4/IL-13-induced apoptosis in NEpCs by inhibiting miR-205-5p. SIRT5 upregulation attenuated IL-4/IL-13-induced inflammatory injury in NEpCs, and SIRT5 knockdown induced opposite effects. miR-205-5p silencing reversed the effects of SIRT5 knockdown on IL-4/IL-13-induced inflammatory injury.
Survival: -
Supported No.:
 1
Description:

CircARF3 inhibited cell apoptosis and inflammation via the miR-205-5p/SIRT5 axis in IL-4/IL-13-treated NEpCs and HDM-treated mice.
Other information
Title:

CircARF3 Mitigates Allergic Rhinitis through Targeting microRNA-205-5p/Sirtuin 5 Axis.

Journal: Int Arch Allergy Immunol
Published: 2023/6/22
PubMed ID: 37343537