circRNA basic information
circBase ID: -
Name: hsa_circ_LARP1B
Synonym: circLARP1B
Host Gene: hsa-miR-578
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TLR4
Associated microRNA: hsa-miR-578
Biological function: Knockdown of circLARP1B promoted the proliferation and cell cycle, and inhibited pyroptosis and inflammation of HG-induced cells
Molecular mechanism: circLARP1B/hsa-miR-578/TLR4 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

CircLARP1B/miR-578/TLR4 axis suppressed the proliferation, blocked cell cycle at the G0-G1 phase, promoted pyroptosis, and inflammatory factor release of renal mesangial cells induced by HG.
Other information
Title:

CircLARP1B promotes pyroptosis of high glucose-induced renal mesangial cells by regulating the miR-578/TLR4 axis.

Journal: Int Urol Nephrol
Published: 2023/6/21
PubMed ID: 37341906