circRNA basic information
circBase ID: -
Name: hsa_circ_SOD2
Synonym: circSOD2
Host Gene: hsa-miR-224-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human chondrocytes (CHON-001 cell line)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PRDX3
Associated microRNA: hsa-miR-224-5p
Biological function: CircSOD2 knockdown alleviated ECM degradation, inflammation, and apoptosis in CHON-001 cell model.
Molecular mechanism: The regulatory function of circSOD2 knockdown on miR-224-5p expression, while miR-224-5p was capable of downregulating PRDX3 expression.
Survival: -
Supported No.:
 1
Description:

knockdown of circSOD2 may serve as an intervention strategy to alleviate OA progression through modulating miR-224-5p/PRDX3 signaling axis.
Other information
Title:

Knockdown of circSOD2 ameliorates osteoarthritis progression via the miR-224-5p/PRDX3 axis.

Journal: J Orthop Surg Res
Published: 2023/6/14
PubMed ID: 37312219