circRNA basic information
circBase ID: -
Name: hsa_circ_DHTKD1
Synonym: circDHTKD1
Host Gene: hsa-miR-338-3p,
 
 
 
Disease basic information
DO ID:
 2841
DO name: asthma
Disease details: Asthma
Species: human
Species details: human
Sample type: cell line
Sample type details: BEAS-2B cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ETS1
Associated microRNA: hsa-miR-338-3p,
Biological function: Inflammatory cytokine and ETS1 expression levels decreased following transfection with small interfering RNA targeting circDHTKD1 or miR-338-3p mimics.
Molecular mechanism: circDHTKD1 directly targeted miR-338-3p, which negatively regulated expression of E26 transformation specific-1 (ETS1).
Survival: -
Supported No.:
 1
Description:

circDHTKD1 exacerbated LPS-triggered inflammation responses in BEAS-2B cells by regulating ETS1 expression by interacting with miR-338-3p, suggesting that circDHTKD1 may serve as a potential therapeutic target against asthma.
Other information
Title:

Circular RNA DHTKD1 targets miR_338_3p/ETS1 axis to regulate the inflammatory response in human bronchial epithelial cells.

Journal: Exp Ther Med
Published: 2023/6/5
PubMed ID: 37273760