circRNA basic information
circBase ID: -
Name: hsa_circ_MALAT1
Synonym: circ-MALAT1
Host Gene: hsa-miR-506-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human colonic epithelial cells (NCM460), CRC cell lines (SW480, SW620, HT29)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KAT6B
Associated microRNA: hsa-miR-506-3p
Biological function: knocking down of circ-MALAT1 suppressed proliferation, migration, and epithelial-mesenchymal transition (EMT) of CRC cells
Molecular mechanism: circ-MALAT1/hsa-miR-506-3p/KAT6B axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ-MALAT1 promotes cell proliferation, migration, and EMT of CRC cells via the miR-506-3p/KAT6B axis, thereby acting as a novel potential therapeutic target for the treatment of colorectal cancer.
Other information
Title:

Circ-MALAT1 accelerates cell proliferation and epithelial mesenchymal transformation of colorectal cancer through regulating miR-506-3p/KAT6B axis.

Journal: Kaohsiung J Med Sci
Published: 2023/6/5
PubMed ID: 37272875