circRNA basic information
circBase ID: hsa_circ_0001504
Name: hsa_circ_PAPD4
Synonym: circPAPD4
Host Gene: hsa-miR-1269a
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human breast cancer cell lines (MCF-7, SKBR-3, BT474, BT549, MDA-MB-468), normal breast epithelial cell line (MCF-10)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: CREBZF, STAT3, ADAR1
Associated microRNA: hsa-miR-1269a
Biological function: circPAPD4 inhibited proliferation and promoted apoptosis in vitro and in vivo
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

Our findings firstly illustrated that circPAPD4/miR-1269a/CREBZF/STAT3/ADAR1 positive feedback loop mediated BC progression, and delivering CREBZF mRNA nanoparticles suppressed BC progression in vitro and in vivo, which might provide novel insights into therapeutic strategies for breast cancer.
Other information
Title:

CREBZF mRNA nanoparticles suppress breast cancer progression through a positive feedback loop boosted by circPAPD4.

Journal: J Exp Clin Cancer Res
Published: 2023/6/2
PubMed ID: 37264406