circRNA basic information
circBase ID: -
Name: hsa_circ_SKA3
Synonym: circSKA3
Host Gene: hsa-miR-1238
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CRC cell line (SW620, HCT116)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: YTHDF2, TAT5A
Associated microRNA: hsa-miR-1238
Biological function: CCK-8, scratch, and transwell assays indicated that circSKA3 could promote the proliferation, migration, and invasion of CRC cell lines for cell detection
Molecular mechanism: circSKA3/hsa-miR-1238/YTHDF2/TAT5A axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

circSKA3 could increase the expression ofYTHDF2 through sponging miR-1238 to decrease the methylation of STAT5A, which could provide a novel target for CRC treatment.
Other information
Title:

circSKA3 promotes colorectal cancer metastases through miR-1238 and methylation.

Journal: Mol Cell Biochem
Published: 2023/5/31
PubMed ID: 37256443