circRNA basic information
circBase ID: hsa_circ_0084054
Name: hsa_circ_ADAM32
Synonym: -
Host Gene: hsa-miR-508-3p
 
 
 
Disease basic information
DO ID:
 9351
DO name: diabetes mellitus
Disease details: gestational diabetes mellitus
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: PTEN
Associated microRNA: hsa-miR-508-3p
Biological function: Silencing hsa_circ_0084054 in PDLCs decreased the expression of inflammatory factors (IL-1beta, IL-6, TNF-alpha), the levels of ROS and MDA, and the proportion of apoptotic cells; conversely, SOD activity was enhanced
Molecular mechanism: hsa_circ_0084054/hsa-miR-508-3p/PTEN signaling axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

hsa_circ_0084054 can aggravate inflammation and promote the progression of periodontitis with diabetes by regulating miR-508-3p/PTEN signaling axis, which may serve as a new target for the intervention of periodontitis with diabetes.
Other information
Title:

Circular RNA hsa_circ_0084054 promotes the progression of periodontitis with diabetes via the miR-508-3p/PTEN axis.

Journal: J Periodontal Res
Published: 2023/5/22
PubMed ID: 37212178