circRNA basic information
circBase ID: hsa_circ_0005239
Name: hsa_circ_GFRA1
Synonym: -
Host Gene: hsa-miR-34a-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: A human normal hepatic cell line (LO2), HCC cell lines (HepG2, MHCC-97H, MHCC-97L, SMMC-7721, Bel-7402), human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PD-L1
Associated microRNA: hsa-miR-34a-5p
Biological function: Knockdown of hsa_circ_0005239 significantly inhibited cell migration, cell invasion, and angiogenesis in HCC, while overexpression showed the opposite effect. In the in vivo assays, hsa_circ_0005239 downregulation suppressed the growth of xenograft tumors in nude mice, which supported that hsa_circ_0005239 is a tumor promoter in HCC.
Molecular mechanism: hsa_circ_0005239/hsa-miR-34a-5p/PD-L1 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

These results revealed the role of hsa_circ_0005239 and the hsa_circ_0005239/miR-34a-5p/PD-L1 axis in HCC, providing a potential diagnostic biomarker and therapeutic target for HCC.
Other information
Title:

Circular RNA hsa_circ_0005239 contributes to hepatocellular carcinoma cell migration, invasion, and angiogenesis by targeting the miR-34a-5p/PD-L1 axis.

Journal: Cell Biol Int
Published: 2023/5/20
PubMed ID: 37208963