circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF215
Synonym: circZNF215, cZNF215
Host Gene: -
 
 
 
Disease basic information
DO ID:
 4928
DO name: intrahepatic cholangiocarcinoma
Disease details: intrahepatic cholangiocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HuCCT1, RBE, HCCC9810
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PRDX1, PTEN
Associated microRNA: -
Biological function: We further revealed that overexpression of cZNF215 promoted iCCA cell growth and metastasis in vitro and in vivo, while cZNF215 knockdown had the opposite effect
Molecular mechanism: PTEN/AKT pathway
Survival: poor
Supported No.:
 1
Description:

Our study demonstrates that cZNF215 facilitates iCCA progression and metastasis by regulating the PTEN/AKT pathway and may serve as a novel prognostic predictor in patients with iCCA.
Other information
Title:

CircZNF215 promotes tumor growth and metastasis through inactivation of the PTEN/AKT pathway in intrahepatic cholangiocarcinoma.

Journal: J Exp Clin Cancer Res
Published: 2023/5/18
PubMed ID: 37198696