circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: circITCH
Host Gene: hsa-miR-421
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: non-tumorigenic hepatocytes (MIHA), hepatocellular carcinoma cell lines (SNU182, SNU387, Hep3B, Huh7), human embryonic kidney cell (HEK293)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: BTG1
Associated microRNA: hsa-miR-421
Biological function: overexpression of circITCH induced cell cycle arrest and apoptosis, and reduced cell viability and colony forming ability in Hep3B and Huh7 cells
Molecular mechanism: circITCH/hsa-miR-421/BTG1 axis, miRNA sponge
Survival: -
Supported No.:
 5
Description:

In conclusion, this study identified a novel circITCH/miR-421/BTG1 axis that restrained the development of HCC, and our findings provided novel biomarkers for the treatment of this disease.
Other information
Title:

Targeting a novel circITCH/miR-421/BTG1 axis is effective to suppress the malignant phenotypes in hepatocellular carcinoma (HCC) cells.

Journal: Cytotechnology
Published: 2023/5/16
PubMed ID: 37187949