circRNA basic information
circBase ID: hsa_circ_0005777
Name: hsa_circ_ARHGEF28
Synonym: circARHGEF28
Host Gene: hsa-miR-671-5p
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human PCa cell lines (PC-3, DU145, LNCap, 22Rv1), immortalized normal uroepithelium cell line (RWPE-1), as well as HEK-293T
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LGALS3BP
Associated microRNA: hsa-miR-671-5p
Biological function: gain- and loss-of function experiments in vitro showed that circARHGEF28 inhibited proliferation, migration, and invasion of PCa. Additionally, circARHGEF28 suppressed PCa progression in vivo
Molecular mechanism: NF-kappaB, circARHGEF28/hsa-miR-671-5p/LGALS3BP/NF-kB axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our findings revealed that circARHGEF28/miR-671-5p/LGALS3BP/NF-¦ĘB may be an important axis that regulates PCa progression.
Other information
Title:

Circular RNA circARHGEF28 inhibited the progression of prostate cancer via the miR-671-5p/LGALS3BP/NF-kappaB axis.

Journal: Cancer Sci
Published: 2023/5/15
PubMed ID: 37186007