circRNA basic information
circBase ID: -
Name: mmu_circ_Kat6b
Synonym: ciRNA-Kat6b
Host Gene: mmu-miRNA-26a
 
 
 
Disease basic information
DO ID:
 0080809
DO name: chronic asthma
Disease details: chronic constrictive injury
Species: mouse
Species details: mouse
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: Kcnk1
Associated microRNA: mmu-miRNA-26a
Biological function: Peripheral nerve injury downregulated ciRNA-Kat6b in the dorsal spinal horn of male mice. Rescuing this downregulation blocked nerve injury-induced increase of miRNA-26a, reversed the miRNA-26a-triggered decrease of potassium channel Kcnk1, a key neuropathic pain player, in the dorsal horn, and alleviates CCI-induced pain hypersensitivities.
Molecular mechanism: The downregulation of ciRNA-Kat6b reduced the accounts of miRNA-26a binding to ciRNA-Kat6b, and elevated the binding accounts of miRNA-26a to the 3 untranslated region of Kcnk1 mRNA and degeneration of Kcnk1 mRNA, triggering in the reduction of KCNK1 protein in the dorsal horn of neuropathic pain mice.
Survival: -
Supported No.:
 1
Description:

The ciRNA-Kat6b/miRNA-26a/Kcnk1 pathway in dorsal horn neurons regulates the development and maintenance of neuropathic pain, ciRNA-Kat6b may be a potential new target for analgesic and treatment strategies.
Other information
Title:

Downregulation of ciRNA-Kat6b in dorsal spinal horn is required for neuropathic pain by regulating Kcnk1 in miRNA-26a-dependent manner.

Journal: CNS Neurosci Ther
Published: 2023/5/5
PubMed ID: 37144575