circRNA basic information
circBase ID: -
Name: hsa_circ_KIF4A
Synonym: circKIF4A
Host Gene: -
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human mammary epithelial cell lines (MCF10A), TNBC cell lines (BT549, HCC38, MDA-MB-453, MDA-MB-468, MDA-MB-231)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: EIF4A3, SDC1
Associated microRNA: -
Biological function: knockdown of circKIF4A suppressed TNBC cell proliferation, migration, and invasion
Molecular mechanism: c-src/FAK signaling pathways, circKIF4A/EIF4A3/SDC1 axis
Survival: -
Supported No.:
 2
Description:

CircKIF4A interacts with EIF4A3 to stabilize SDC1 mRNA, which activates the c-src/FAK signaling pathways and promotes TNBC progression. This may provide a potential therapy for TNBC treatment.
Other information
Title:

CircKIF4A combines EIF4A3 to stabilize SDC1 expression to activate c-src/FAK and promotes TNBC progression.

Journal: Cell Signal
Published: 2023/5/1
PubMed ID: 37121557