circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK2
Synonym: circHIPK2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10763
DO name: hypertension
Disease details: hypertension
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ADAM
Associated microRNA: -
Biological function: circHIPK2 promoted the Angiotensin II (AngII)-induced VSMC phenotype switching
Molecular mechanism: circHIPK2/hsa-miR-145-5p/ADAM axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Functional studies showed that circHIPK2 promoted the Angiotensin II (AngII)-induced VSMC phenotype switching by acting as the sponge of miR-145-5p, thereby upregulating the expression of a disintegrin and metalloprotease (ADAM) 17.
Other information
Title:

CircHIPK2 facilitates phenotypic switching of vascular smooth muscle cells in hypertension.

Journal: J Hum Hypertens
Published: 2023/4/27
PubMed ID: 37100987