circRNA basic information
circBase ID: -
Name: hsa_circ_HECTD1
Synonym: CircHECTD1
Host Gene: hsa-miR-138-5p
 
 
 
Disease basic information
DO ID:
 2316
DO name: brain ischemia
Disease details: Myocardial ischemia-reperfusion injury
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: H9c2 cells (rat cardiac myoblast)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ROCK2
Associated microRNA: hsa-miR-138-5p
Biological function: CircHECTD1 and ROCK2 were upregulated in the rat MIRI model, while miR-138-5p was decreased. CircHECTD1 knockdown alleviated H/R-induced inflammation in H9c2 cells.
Molecular mechanism: CircHECTD1 promoted H/R-induced inflammation and cell apoptosis by inhibiting miR-138-5p. miR-138-5p alleviated H/R-induced inflammation, while ectopic ROCK2 antagonized such effect of miR-138-5p.
Survival: -
Supported No.:
 1
Description:

Our research suggested that the circHECTD1-modulated miR-138-5p suppressing is responsible for ROCK2 activation during H/R-induced inflammatory response, providing a novel insight into MIRI-associated inflammation.
Other information
Title:

CircHECTD1 promoted MIRI-associated inflammation via inhibiting miR-138-5p and upregulating ROCK2.

Journal: Kaohsiung J Med Sci
Published: 2023/4/25
PubMed ID: 37096660