circRNA basic information
circBase ID: -
Name: mmu_circ_kif26b
Synonym: circRNA_kif26b
Host Gene: mmu-miR-346-3p
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: lung injury
Species: mouse
Species details: mouse
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: mmu-miR-346-3p
Biological function: circ_kif26b knockdown or miR-346-3p overexpression attenuated PS-MPs-induced MLE12 cell senescence and secretion of the SASP cytokines IL-6 and IL-8. However, down-regulation of circ_kif26b and miR-346-3p reversed this depressive effect
Molecular mechanism: circ_kif26b/mmu-miR-346-3p axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Overall, circ_kif26b mediates alveolar epithelial cell senescence through miR-346-3p and participates in PS-MPs-induced lung inflammation.
Other information
Title:

The regulation of circRNA_kif26b on alveolar epithelial cell senescence via miR-346-3p is involved in microplastics-induced lung injuries.

Journal: Sci Total Environ
Published: 2023/4/22
PubMed ID: 37084911