circRNA basic information
circBase ID: -
Name: -
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-135a-5p
 
 
 
Disease basic information
DO ID:
 1733
DO name: cryptosporidiosis
Disease details: cryptosporidiosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: STAT1
Associated microRNA: hsa-miR-135a-5p
Biological function: One up-regulated circRNA ciRS-7 was found previously by our group to promote in vitro propagation of C. parvum in HCT-8 cells
Molecular mechanism: ciRS-7/hsa-miR-135a-5p/STAT1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Further study revealed that ciRS-7 could sponge miR-135a-5p to positively regulate the protein levels of STAT1 and phosphorylated STAT1 (p-STAT1) and thus promote C. parvum propagation in HCT-8 cells.
Other information
Title:

Circular RNA ciRS-7 affects the propagation of Cryptosporidium parvum in HCT-8 cells via regulating miR-135a-5p/stat1 axis.

Journal: Acta Trop
Published: 2023/4/21
PubMed ID: 37080266