circRNA basic information
circBase ID: -
Name: hsa_circ_CLNS1A
Synonym: circCLNS1A
Host Gene: -
 
 
 
Disease basic information
DO ID:
 687
DO name: hepatoblastoma
Disease details: hepatoblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human HB cell lines (HuH6, HepG2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LARP1, DKK4
Associated microRNA: -
Biological function: -
Molecular mechanism: circCLNS1A/LARP1/DKK4/beta-catenin axis
Survival: -
Supported No.:
 1
Description:

This study indicates that upregulated protein level of O-GlcNAcylated LARP1 mediated by circCLNS1A promotes the tumorigenesis and progression of HB through LARP1/DKK4/beta-catenin axis.
Other information
Title:

O-GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/beta-catenin signalling.

Journal: Clin Transl Med
Published: 2023/4/19
PubMed ID: 37070251