circRNA basic information
circBase ID: hsa_circ_0000231
Name: hsa_circ_ARHGAP12
Synonym: circ_0000231
Host Gene: hsa-miR-590-5p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PDCD4
Associated microRNA: hsa-miR-590-5p
Biological function: knockdown of circ_0000231 and overexpression of miR-590-5p could suppress ox-LDL-elicited above effects on apoptosis, autophagy and inflammatory response, accompanied with PDCD4 downregulation
Molecular mechanism: circ_0000231/hsa-miR-590-5p/PDCD4 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Downregulation of circ_0000231 suppresses HUVECs from ox-LDL-induced injury partially through regulating miR-590-5p/PDCD4 axis via competing endogenous RNA mechanism, showing a novel potential target for the pathology and treatment of endothelial injury in AS.
Other information
Title:

Inhibition of circ_0000231 suppresses oxidized low density lipoprotein-induced apoptosis, autophagy and inflammation in human umbilical vein endothelial cells by regulating miR-590-5p/PDCD4 axis.

Journal: Clin Hemorheol Microcirc
Published: 2023/4/18
PubMed ID: 37066904