circRNA basic information
circBase ID: hsa_circ_0082476
Name: -
Synonym: circ_0082476
Host Gene: hsa-miR-138-5p
 
 
 
Disease basic information
DO ID:
 8893
DO name: psoriasis
Disease details: psoriasis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human keratinocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BRD4
Associated microRNA: hsa-miR-138-5p
Biological function: Knockdown of circ_0082476 reduced cell proliferation, invasion and migration in IL-22-treated HaCaT cells.
Molecular mechanism: Circ_0082476 induced sponge effect on miR-138-5p.
Survival: -
Supported No.:
 1
Description:

These findings disclosed that circ_0082476 facilitated the IL22-induced epidermis cell injury in psoriasis through the upregulation of BRD4 via binding to miR-138-5p.
Other information
Title:

Circ_0082476 targets miR-138-5p to promote proliferation, invasion, migration and inflammation in IL-22-treated human keratinocytes by upregulating BRD4.

Journal: Int Immunopharmacol
Published: 2023/4/13
PubMed ID: 37044031