circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA-000911
Host Gene: hsa-miR-449a
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human breast cancer cell lines (MCF-7, MDA-MB-231, MDA-MB-468, MDA-MB-453, SKBR-3, T47D), normal breast epithelial cell line (MCF-10A)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-449a
Biological function: suppressed cell proliferation, migration and invasion, and promoted the apoptosis of breast cancer cells
Molecular mechanism: targeting miR_449a and elevated Notch1 expression
Survival: -
Supported No.:
 1
Description:

On the whole, our findings indicate that circRNA-000911 plays an anti-oncogenic role in breast cancer and may thus serve as a promising therapeutic target for patients with breast cancer. Therefore, the overexpression of circRNA-000911 may provide a future direction which may aid in the development of a novel treatment strategy for breast cancer.
Other information
Title:

Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis.

Journal: Int J Oncol
Published: 2018/2/13
PubMed ID: 29431182