circRNA basic information
circBase ID: hsa_circ_0005218
Name: hsa_circ_FAM120A
Synonym: -
Host Gene: hsa-miR-31-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human HCC cell lines (MHCC-97H, SMMC-7721, Hep3B, Huh7, HepG2, SK-HEP-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CDK1
Associated microRNA: hsa-miR-31-5p
Biological function: the promotion effects of circ_0005218 on HCC cells in term of proliferation, invasion and metastasis were confirmed both in vitro and vivo by gain- and loss-of function assays
Molecular mechanism: circ_0005218/hsa-miR-31-5p/CDK1 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

Taken together, the present study indicates that circ_0005218 absorbed miR-31-5p as a sponge to weaken its suppression on CDK1 expression, and thus boost HCC cell invasion and migration, which would act as a potential biomarker to predict the HCC early recurrence and as a new therapeutic target for treatment of HCC.
Other information
Title:

Circular RNA hsa_circ_0005218 promotes the early recurrence of hepatocellular carcinoma by targeting the miR-31-5p/CDK1 pathway.

Journal: Heliyon
Published: 2023/4/11
PubMed ID: 37035389