circRNA basic information
circBase ID: hsa_circ_0000231
Name: hsa_circ_ARHGAP12
Synonym: circ_0000231
Host Gene: hsa-miR-140
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human ovarian cancer cell line (SKOV3) , PTX-resistant OC line (SKOV3-TR30)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RAP1B
Associated microRNA: hsa-miR-140
Biological function: Depletion of circ_0000231 could inhibit the resistance, proliferation, invasion, migration and EMT and promoted the apoptosis of PTX-resistant OC cells. The opposite effects were observed by overexpression of circ_0000231. Furthermore, the effect of circ_0000231 on the PTX sensitivity of OC cells was investigated by using xenograft tumor models, and circ_0000231 knockdown increased PTX sensitivity of OC in vivo
Molecular mechanism: circ_0000231/hsa-miR-140/RAP1B axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

we demonstrated that circ_0000231 acted as a sponge for miR-140, and RAP1B was the target gene of miR-140.
Other information
Title:

Circ_0000231 promotes paclitaxel resistance in ovarian cancer by regulating miR-140/RAP1B.

Journal: Am J Cancer Res
Published: 2023/4/11
PubMed ID: 37034216