circRNA basic information
circBase ID: -
Name: hsa_circ_EPS15
Synonym: circEPS15
Host Gene: hsa-miR-24-3p
 
 
 
Disease basic information
DO ID:
 14330
DO name: Parkinson disease
Disease details: Parkinson disease
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PINK1
Associated microRNA: hsa-miR-24-3p
Biological function: Low expression of circEPS15 was found in PD patients and there was a negative positive correlation between the circEPS15 level and severity of PD motor symptoms, while overexpression of circEPS15 protected DA neurons against neurotoxin-induced PD-like neurodegeneration in vitro and in vivo
Molecular mechanism: circEPS15/hsa-miR-24-3p/PINK1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

circEPS15 rescued DA neuronal degeneration through the MIR24-3p-PINK1 axis-mediated improvement of mitochondrial function.
Other information
Title:

CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy.

Journal: Autophagy
Published: 2023/4/5
PubMed ID: 37014258