circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: circPVT1
Host Gene: hsa-miR-181a-2-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human, mouse breast cancer cell lines, human embryonic kidney cell line (HEK293T)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: ESR1
Associated microRNA: hsa-miR-181a-2-3p
Biological function: Anti-sense oligonucleotide (ASO)-targeting circPVT1 inhibits ERalpha-positive breast cancer cell and tumor growth, re-sensitizing tamoxifen-resistant ERalpha-positive breast cancer cells to tamoxifen treatment.
Molecular mechanism: circPVT1/hsa-miR-181a-2-3p/ESR1 axis, miRNA sponge
Survival: -
Supported No.:
 4
Description:

Thus, circPVT1 may serve as a diagnostic biomarker and therapeutic target for ERalpha-positive breast cancer in the clinic.
Other information
Title:

CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS.

Journal: EMBO J
Published: 2023/4/4
PubMed ID: 37009655