circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: circITCH
Host Gene: hsa-miR-579-3p
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: acute kidney injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HK-2 cells.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: ZEB2
Associated microRNA: hsa-miR-579-3p
Biological function: CircITCH overexpression restored cell viability in LPS-treated HK-2 cells and restrained apoptosis and inflammatory cytokine production.
Molecular mechanism: CircITCH negatively regulated miR-579-3p, thereby upregulating ZEB2 expression.
Survival: -
Supported No.:
 1
Description:

circITCH alleviates LPS-induced HK-2 cell injury by regulating miR-579-3p/ZEB2 signal axis, which provides a theoretical basis for AKI therapy.
Other information
Title:

Inhibition of sepsis-induced acute kidney injury via the circITCH-miR-579-3p-ZEB2 axis.

Journal: Environ Toxicol
Published: 2023/4/1
PubMed ID: 36999488