circRNA basic information
circBase ID: hsa_circ_0001445
Name: hsa_circ_SMARCA5
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human GBM cell lines (A172, CAS1, DBTRG, SNB19, U87MG)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SRSF1, SRSF3, PTB
Associated microRNA: -
Biological function: inhibits migration of glioblastoma multiforme cells
Molecular mechanism: Regulating a Molecular Axis Involving Splicing Factors SRSF1/SRSF3/PTB
Survival: -
Supported No.:
 3
Description:

Collectively, our data show circSMARCA5 as a promising druggable tumor suppressor in GBM and suggest that it may exert its function by tethering the RBP SRSF1.
Other information
Title:

CircSMARCA5 Inhibits Migration of Glioblastoma Multiforme Cells by Regulating a Molecular Axis Involving Splicing Factors SRSF1/SRSF3/PTB.

Journal: Int J Mol Sci
Published: 2018/2/9
PubMed ID: 29415469