circRNA basic information
circBase ID: hsa_circ_0000047
Name: -
Synonym: -
Host Gene: hsa-miR-6720-5p
 
 
 
Disease basic information
DO ID:
 8947
DO name: diabetic retinopathy
Disease details: diabetic retinopathy
Species: human
Species details: human
Sample type: cell line
Sample type details: human retinal microvascular endothelial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: CYB5R2
Associated microRNA: hsa-miR-6720-5p
Biological function: Cell functional experiments showed that hsa_circ_0000047 overexpression restrained viability, inflammation, migration, invasion, and angiogenesis of HG-induced hRMECs.
Molecular mechanism: hsa_circ_0000047 could sponge miR-6720-5p to regulate CYB5R2 expression in hRMECs.
Survival: -
Supported No.:
 1
Description:

Our study revealed that hsa_circ_0000047 alleviated inflammation and angiogenesis in HG-induced hRMECs by targeting the miR-6720-5p/CYB5R2 axis, which may be a novel biomarker for DR therapy.
Other information
Title:

hsa_circ_0000047 targeting miR-6720-5p/CYB5R2 axis alleviates inflammation and angiogenesis in diabetic retinopathy.

Journal: Arch Physiol Biochem
Published: 2023/3/28
PubMed ID: 36971486