circRNA basic information
circBase ID: -
Name: hsa_circ_OXNAD1
Synonym: circOXNAD1
Host Gene: hsa-miR-29a-3p
 
 
 
Disease basic information
DO ID:
 319
DO name: spinal cord disease
Disease details: spinal cord ischemia-reperfusion injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human umbilical cord MSCs (HucMSCs), PC12 cell line
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXO3a
Associated microRNA: hsa-miR-29a-3p
Biological function: Hypoxia-HucMSCs-derived exosomal circOXNAD1 alleviated the spinal cord tissue injury in SCI, improved limb motor function, decreased production of inflammatory factors including the IL-1beta, IL-6, and TNF-alpha
Molecular mechanism: circOXNAD1/hsa-miR-29a-3p/FOXO3a axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

The exosomal circOXNAD1 alleviated SCI through sponging miR-29a-3p and consequently elevated the FOXO3a expression.
Other information
Title:

Hypoxia-treated umbilical mesenchymal stem cell alleviates spinal cord ischemia-reperfusion injury in SCI by circular RNA circOXNAD1/ miR-29a-3p/ FOXO3a axis.

Journal: Biochem Biophys Rep
Published: 2023/3/28
PubMed ID: 36969321