circRNA basic information
circBase ID: -
Name: hsa_circ_RERE
Synonym: circRERE
Host Gene: hsa-miR-6837-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: MAVS
Associated microRNA: hsa-miR-6837-3p
Biological function: Overexpression of circRERE inhibits the malignant behaviors of colorectal cancer in vitro and in vivo, while knockdown exhibits the opposite effects
Molecular mechanism: circRERE/hsa-miR-6837-3p/MAVS axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

These results uncover modulatory axis constituting of EP300/circRERE/miR-6837-3p/MAVS and its essential roles in antitumor immunity, and demonstrate that circRERE-AAV might represent a new therapeutic avenue to prime immune responses and boost the effects of immunotherapy in clinic.
Other information
Title:

A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer.

Journal: Clin Cancer Res
Published: 2023/3/24
PubMed ID: 36951687