circRNA basic information
circBase ID: hsa_circ_0002715
Name: -
Synonym: circ_0002715
Host Gene: hsa-miR-127-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: cell line
Sample type details: CHON-001 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LXN
Associated microRNA: hsa-miR-127-5p
Biological function: Circ_0002715 silencing inhibited inflammation, apoptosis, and ECM degradation in IL-1beta-interfered CHON-001 cells.
Molecular mechanism: Circ_0002715 could sponge miR-127-5p, and miR-127-5p could target LXN.
Survival: -
Supported No.:
 1
Description:

Circ_0002715 might be a new therapeutic target for OA, which regulated miR-127-5p/LXN axis to promote IL-1beta-induced chondrocyte injury.
Other information
Title:

Circ_0002715 promotes the development of osteoarthritis through regulating LXN by sponging miR-127-5p.

Journal: J Orthop Surg Res
Published: 2023/3/24
PubMed ID: 36949500