circRNA basic information
circBase ID: -
Name: hsa_circ_LPAR3
Synonym: circLPAR3
Host Gene: hsa-miR-513b-5p
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: PCa cell lines (PC-3, LNCaP, VCaP, DU145), human normal prostate epithelial cell line (RWPE-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: JPT1
Associated microRNA: hsa-miR-513b-5p
Biological function: Repression of circLPAR3 depressed cell advancement, and restrained glycolysis, but enhanced the radiosensitivity of PCa cells
Molecular mechanism: circLPAR3/hsa-miR-513b-5p/JPT1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In summary, the knockdown of circLPAR3 reduces glycolysis, but promotes PCa radiosensitivity via the miR-513b-5p/JPT1 axis, discovering a novel mechanism in PCa progression.
Other information
Title:

Circular RNA LPAR3 targets JPT1 via microRNA-513b-5p to facilitate glycolytic activation but repress prostate cancer radiosensitivity.

Journal: Acta Biochim Pol
Published: 2023/3/18
PubMed ID: 36929708