circRNA basic information
circBase ID: hsa_circ_0075723
Name: -
Synonym: circ_0075723
Host Gene: hsa-miR-155-5p
 
 
 
Disease basic information
DO ID:
 552
DO name: pneumonia
Disease details: pneumonia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: THP-1 cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: NLRP3
Associated microRNA: hsa-miR-155-5p
Biological function: circ_0075723 in macrophages promoted VE-cadherin expression in endothelial cells through inhibiting the release of NLRP3 inflammasome-related cytokines, IL-1beta and IL-18, and protects endothelial cell integrity.
Molecular mechanism: circ_0075723 inhibited macrophage pyroptosis via sponging miR-155-5p which promoted SHIP1 expression directly.
Survival: -
Supported No.:
 1
Description:

circRNAs could be used as possible potential diagnostic and therapeutic targets for pneumonia-induced sepsis.
Other information
Title:

CircRNA_0075723 protects against pneumonia-induced sepsis through inhibiting macrophage pyroptosis by sponging miR-155-5p and regulating SHIP1 expression.

Journal: Front Immunol
Published: 2023/3/17
PubMed ID: 36923408