circRNA basic information
circBase ID: hsa_circ_0002938
Name: hsa_circ_CRIM1
Synonym: circCRIM1
Host Gene: hsa-miR-342-3p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ESCC cell lines (TE-1, KYSE30, KYSE410, KYSE150)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TCF12
Associated microRNA: hsa-miR-342-3p
Biological function: Increased expression of circCRIM1 was positively correlated with clinical parameters of ESCC patients including tumor-node-metastasis (TNM) stage, tumor invasion range, and lymph node metastasis. The knockdown of circCRIM1 suppressed proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in ESCC cells.
Molecular mechanism: circCRIM1/hsa-miR-342-3p/TCF12 axis, miRNA sponge, EMT
Survival: -
Supported No.:
 1
Description:

Taken together, circCRIM1 facilitates the progression of ESCC by sponging miR-342-3p to regulate TCF12 and promote EMT, and the circCRIM1/miR-342-3p/TCF12 axis may be regarded as a potential predictive biomarker and therapeutic target for treating ESCC.
Other information
Title:

Circular RNA hsa_circ_0002938 (circCRIM1) promotes the progression of esophageal squamous cell carcinoma by upregulating transcription factor 12.

Journal: Neoplasma
Published: 2023/3/15
PubMed ID: 36916930