circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-124-3p, hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 9351
DO name: diabetes mellitus
Disease details: diabetes
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: -
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-124-3p, hsa-miR-338-3p
Biological function: -
Molecular mechanism: circHIPK3 acts by sequestering a group of microRNAs, including hsa-miR-124-3p and hsa-miR-338-3p, and by regulating the expression of key beta-cell genes, such as Slc2a2, Akt1, and Mtpn
Survival: -
Supported No.:
 2
Description:

Our findings point to circular RNAs as novel regulators of beta-cell activities and suggest an involvement of this novel class of non-coding RNAs in beta-cell dysfunction under diabetic conditions.
Other information
Title:

Circular RNAs as novel regulators of beta-cell functions in normal and disease conditions.

Journal: Mol Metab
Published: 2018/2/6
PubMed ID: 29396373