circRNA basic information
circBase ID: -
Name: hsa_circ_AAGAB
Synonym: circAAGAB
Host Gene: hsa-miR-378
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: breast cancer cell lines (MCF7, MDA-MB-231, HEK293T)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: KIAA1522, NKX3-1, JADE3
Associated microRNA: hsa-miR-378
Biological function: circAAGAB reduced cell colony formation, cell migration, and signaling through p38 MAPK pathway, as well as increased radiosensitivity.
Molecular mechanism: circAAGAB/hsa-miR-378 axis, miRNA sponge, p38 MAPK pathway
Survival: -
Supported No.:
 1
Description:

These findings suggest that the oxygen-responsive circAAGAB acts as a tumor suppressor in breast cancer, and may contribute to the development of a more specific therapeutic regimen for breast cancer.
Other information
Title:

Hypoxia-responsive circular RNA circAAGAB reduces breast cancer malignancy by activating p38 MAPK and sponging miR-378 h.

Journal: Cancer Cell Int
Published: 2023/3/11
PubMed ID: 36899354