circRNA basic information
circBase ID: -
Name: hsa_circ_DNAJC11
Synonym: circDNAJC11
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human BC cell lines (MCF-7, MDA-MB-231, BT-549, MDA-MB-453, SK-BR-3), normal breast epithelial cell lines (MCF-10A)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: TAF15, MAPK6
Associated microRNA: -
Biological function: gain- and loss-of-function experiments in vitro and in vivo showed that circDNAJC11 promoted BC cell proliferation, migration, invasion, and tumor growth
Molecular mechanism: circDNAJC11/TAF15/MAPK6, MAPK signaling pathway
Survival: poor
Supported No.:
 1
Description:

The circDNAJC11/TAF15/MAPK6 axis played a crucial role in the progression and development of BC, suggesting that circDNAJC11 might be a novel biomarker and therapeutical target for BC.
Other information
Title:

CircDNAJC11 interacts with TAF15 to promote breast cancer progression via enhancing MAPK6 expression and activating the MAPK signaling pathway.

Journal: J Transl Med
Published: 2023/3/10
PubMed ID: 36895010