circRNA basic information
circBase ID: hsa_circ_0068706
Name: hsa_circ_DLG1
Synonym: -
Host Gene: hsa-miR-144
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CALU3, SPCA1, A549, H1229, a human bronchial epithelial cell line (16HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AKT
Associated microRNA: hsa-miR-144
Biological function: Knockdown of circDLG1 results in suppression of the proliferation activity and metastasis ability of NSCLC
Molecular mechanism: circDLG1/hsa-miR-144/AKT axis, miRNA sponge, mTOR signaling
Survival: -
Supported No.:
 2
Description:

In conclusion, we demonstrate that circDLG1 promotes the pathogenesis and progression of NSCLC by regulating the miR-144/AKT/mTOR signaling axis, providing potential diagnostic and therapeutic targets for designing innovative treatment strategies.
Other information
Title:

Circular RNA circDLG1 (has_circ_0068706) functions as an oncogene in nonsmall cell lung cancer through regulating AKT/mTOR signaling and direct binding to miR-144.

Journal: Kaohsiung J Med Sci
Published: 2023/3/7
PubMed ID: 36876724