circRNA basic information
circBase ID: -
Name: hsa_circ_GRAMD1B
Synonym: circGRAMD1B
Host Gene: hsa-miR-4428
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal bronchial epithelial cell, human LUAD cells (H1975, H1395, H1299, H441)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOX4, MEX3A
Associated microRNA: hsa-miR-4428
Biological function: circGRAMD1B was upregulated in LUAD cells and promoted the migration, invasion, and EMT of LUAD cells
Molecular mechanism: circGRAMD1B/hsa-miR-4428/SOX4/MEX3A axis, miRNA sponge, PI3K/AKT pathway
Survival: -
Supported No.:
 1
Description:

In conclusion, circGRAMD1B is discovered to modulate miR-4428/SOX4/MEX3A axis to further activate PI3K/AKT pathway, finally boosting migration, invasion, and EMT of LUAD cells.
Other information
Title:

circGRAMD1B contributes to migration, invasion and epithelial-mesenchymal transition of lung adenocarcinoma cells via modulating the expression of SOX4.

Journal: Funct Integr Genomics
Published: 2023/3/4
PubMed ID: 36867268