circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: cir-ITCH, circ-ITCH
Host Gene: hsa-miR-17, hsa-miR-224
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: EJ, T24
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PTEN, p21
Associated microRNA: hsa-miR-17, hsa-miR-224
Biological function: inhibited cells proliferation, migration, invasion and metastasis
Molecular mechanism: circ-ITCH up-regulates the expression of hsa-miR-17 and hsa-miR-224 target gene p21 and PTEN through sponging hsa-miR-17 and hsa-miR-224
Survival: better
Supported No.:
 1
Description:

Circ-ITCH acts as a tumor suppressor by a novel circ-ITCH/miR-17, miR-224/p21, PTEN axis, which may provide a potential biomarker and therapeutic target for the management of BCa.
Other information
Title:

Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression.

Journal: Mol Cancer
Published: 2018/2/2
PubMed ID: 29386015