circRNA basic information
circBase ID: hsa_circ_0004771
Name: hsa_circ_NRIP1
Synonym: circNRIP1
Host Gene: hsa-miR-541-5p, hsa-miR-3064-5p
 
 
 
Disease basic information
DO ID:
 1781
DO name: thyroid gland cancer
Disease details: thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human thyroid follicular epithelial cell line (Nthy-ori3-1), PTC cell lines (TPC1, K1, IHH4, BCPAP)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PKM2
Associated microRNA: hsa-miR-541-5p, hsa-miR-3064-5p
Biological function: circNRIP1 significantly promoted glycolysis, PTC cell proliferation in vitro, and tumorigenesis in vivo
Molecular mechanism: circNRIP1/hsa-miR-541-5p/ hsa-miR-3064-5p/PKM2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Therefore, circNRIP1 can be a prognostic biomarker and therapeutic target for PTC by acting as a sponge for oncogenic miR-541-5p and miR-3064-5p to upregulate PKM2 expression.
Other information
Title:

ALKBH5-induced circular RNA NRIP1 promotes glycolysis in thyroid cancer cells by targeting PKM2.

Journal: Cancer Sci
Published: 2023/3/1
PubMed ID: 36851875